Synthesis and potential application of a frog-like ether molecule
Keywords:
Molecular design, Acetylene cyclization reaction, 1, 3-dioxopentane structure, Ether synthesisAbstract
Using the methods of cheminformatics, we have designed an interesting frog-like molecule called "frog ether" and studied its synthesis steps. The molecule has a 1, 3-dioxopentane structure and may have antifungal effects similar to some drug molecules. In addition, ring-opening polymerization based on 1, 3-dioxopentane can form solid electrolytes, which also have potential in the battery energy neighborhood.
References
Helesbeux, J.; Peyronnet, D.; Labaïed, M.; Grellier, P.; Frappier, F.; Seraphin, D.; Richomme, P.; Duval, O. Synthesis and Antimalarial Activity of Some New 1,2-Dioxolane Derivatives, J. Enzyme Inhib. Med. Chem. 2002, 17, 431-437.
Phillipson, W.D.; Rinehart, K.L. Jr. Antifungal peroxide-containing acids from two Caribbean sponges. J. Am. Chem. Soc. 1983, 105 (26), 7735-7736.
Z. Huang; H. Zeng; M. Xie; X. Lin; Z. Huang; Y. Shen; Y. Huang. A Stable Lithium–Oxygen Battery Electrolyte Based on Fully Methylated Cyclic Ether. Angew. Chem. Int. Ed. 2019, 58, 2345– 2349.
Utomo, N. W.; Deng Y.; Zhao, Q; Liu, X; Archer, L.A. Structure and evolution of quasi-solid-state hybrid electrolytes formed inside electrochemical cells. Adv. Mater. 2022, 34, 2110333.
Jepsen, T. H.; Kristensen, J. L. In Situ Generation of the Ohira–Bestmann Reagent from Stable Sulfonyl Azide: Scalable Synthesis of Alkynes from Aldehydes. J. Org. Chem. 2014, 79 (19), 9423–9426.
Belot, S.; Quintard, A.; Krause, N.; Alexakis, A. Organocatalyzed Conjugate Addition of Carbonyl Compounds to Nitrodienes/Nitroenynes and Synthetic Applications. Adv. Synth. Catal. 2010, 352 (4), 667–695.
Cheng, S.; Tieu, P.; Gao, W.; Hu, J.; Feng, W.; He, J.; Pan, X.; Xu, Z. Crystallinity after Decarboxylation of a Metal–Carboxylate Framework: Indestructible Porosity for Catalysis. Dalton Trans. 2020, 49 (34), 11902–11910.
王积涛; 王永梅; 张宝申; 胡青眉; 庞美丽, 有机化学,第三版.;南开大学出版社: 天津, 2009, p. 363.
Cheng, S.; Tieu, P.; Gao, W.; Hu, J.; Feng, W.; He, J.; Pan, X.; Xu, Z. Crystallinity after Decarboxylation of a Metal–Carboxylate Framework: Indestructible Porosity for Catalysis. Dalton Trans. 2020, 49 (34), 11902–11910.
Qi, C.; Qin, T.; Suzuki, D.; Porco, J. A. Total Synthesis and Stereochemical Assignment of (±)-Sorbiterrin A. J. Am. Chem. Soc. 2014, 136 (9), 3374–3377.
王积涛; 王永梅; 张宝申; 胡青眉; 庞美丽, 有机化学, 第三版.; 南开大学出版社: 天津, 2009, p. 390.
Furrow, M. E.; Myers, A. G. Practical Procedures for the Preparation of N - Tert-Butyldimethylsilylhydrazones and Their Use in Modified Wolff−Kishner Reductions and in the Synthesis of Vinyl Halides and gem -Dihalides. J. Am. Chem. Soc. 2004, 126 (17), 436–5445.